The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells.
C. M. Russell, K. Schaefer, A. Dixson, A. Gray, R. J. Pyron, D. Alves, N. Moore, E. Conley, T. White, T. Do, G. King, F. N. Barrera
This study reveals that Candidalysin polymerizes in solution to form membrane pores, damaging epithelial cells, and identifies polymerization as a therapeutic target for candidiasis.
bioRxiv · Nov 11, 2021 · PreprintBiophysics