T. White

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells.

This study reveals that Candidalysin polymerizes in solution to form membrane pores, damaging epithelial cells, and identifies polymerization as a therapeutic target for candidiasis.

Selection for Decreased BRCA2 Functional Activity in Homo sapiens After Divergence from the Chimpanzee-Human Last Common Ancestor

The paper identifies a human-specific BRCA2 variant that reduces DNA repair ability, suggesting positive selection for decreased BRCA2 function in human evolution.

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

Test Agreement Between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 Assays at High Cycle Threshold Ranges

This study compares the agreement between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 assays at high cycle threshold values, finding close agreement despite high variability.

Defining the core essential genome of Pseudomonas aeruginosa

The paper defines the core essential genome of Pseudomonas aeruginosa by analyzing multiple strains and growth conditions using Tn-Seq and a novel statistical model, identifying 321 core essential genes.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

Comparing colours using visual models

The paper evaluates methods for estimating colour differences in colour spaces and proposes a permutation-based approach to improve accuracy and robustness.