Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways
K. Kesh, V. T. Garrido, A. Doesch, B. Durden, V. K. Gupta, N. S. Sharma, M. Lyle, N. Nagathihalli, N. Merchant, A. Saluja, S. Banerjee
This study shows that stromal IL6 promotes stem-like cells and metabolic reprogramming in pancreatic tumors, creating an immune-evasive microenvironment that can be targeted to improve checkpoint inhibitor therapy.
Cell Death & Disease · Nov 11, 2020Peer-reviewedCancer Biology