Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cells
L. Borkner, A. Drabig, X. Zheng, J. Drylewicz, T. Marandu, M. Baliu-Pique, S. van Duikeren, R. Arens, K. Tesselaar, J. A. Borghans, L. Cicin-Sain
The paper shows that effector memory T-cells (TEM) proliferate during persistent CMV infection, maintaining memory inflation, while central memory T-cells (TCM) do not proliferate as much.
bioRxiv · Dec 20, 2018 · PreprintImmunology