Author

L. Borkner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

L. Cicin-Sain· 4 shared X. Zheng· 3 shared J. A. Borghans· 2 shared J. Drylewicz· 2 shared K. Tesselaar· 2 shared M. Baliu-Pique· 2 shared A. C. Swain· 1 shared A. Drabig· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersImmunology

L. Cicin-Sain

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4 papers

Recent·Most cited

NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells

M. Z. Chaudhry, L. Borkner, F. Berberich-Siebelt, L. Cicin-Sain

This study shows that NFATc1 and NFATc2 are essential for the long-term inflation of MCMV-specific CD8 T cells during viral latency, but not for acute infection responses.

bioRxiv · May 2, 2023 · PreprintImmunology

Turnover of MCMV-expanded CD8+ T-cells is similar to that of memory phenotype T-cells and independent of the magnitude of the response

M. Baliu-Pique, J. Drylewicz, X. Zheng, L. Borkner, A. C. Swain, S. Otto, R. J. de Boer, K. Tesselaar, L. Cicin-Sain, J. A. Borghans

The paper compares the turnover rates of CMV-specific CD8+ T-cells to memory phenotype CD8+ T-cells, finding they are similar regardless of response magnitude.

bioRxiv · Nov 3, 2021 · PreprintImmunology

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

X. Zheng, J. D. Oduro, J. D. Boehme, L. Borkner, T. Ebensen, U. Heise, M. Gereke, M. Pils, A. Krmpotic, C. Guzman, D. Bruder, L. Cicin-Sain

This paper shows that intranasal immunization with an MCMV-based vaccine vector induces lung-resident memory CD8+ T cells that protect against influenza challenge.

PLOS Pathogens · Sep 16, 2019Peer-reviewedImmunology

Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cells

L. Borkner, A. Drabig, X. Zheng, J. Drylewicz, T. Marandu, M. Baliu-Pique, S. van Duikeren, R. Arens, K. Tesselaar, J. A. Borghans, L. Cicin-Sain

The paper shows that effector memory T-cells (TEM) proliferate during persistent CMV infection, maintaining memory inflation, while central memory T-cells (TCM) do not proliferate as much.

bioRxiv · Dec 20, 2018 · PreprintImmunology