ImmunologybioRxivPreprint
OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
G. Beyrend, T. C. van der Sluis, E. T. I. van der Gracht…·R. Arens
This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.