Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer
Z. X. Malchiodi, A. A. Lekan, R. K. Suter, A. Deshpande, I. Peran, B. T. Harris, A. Duttargi, M.-J. Chien, S. Hariharan, L. Wetherill, S. Arslan, S. A. Jablonski, W. J. Ho, M. Afifi, E. J. Fertig, L. M. Weiner
The paper identifies periductal fibroblast density as a key factor in immune exclusion in pancreatic cancer, showing that CD44-dependent stromal checkpoints restrict leukocyte access to tumor epithelium.
bioRxiv · May 23, 2024Cancer Biology