B. Gyorffy

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

The paper identifies novel regulators of quiescence in colon cancer stem cells using RNA-sequencing and shows their potential as therapeutic targets.

A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors

This study performs a meta-analysis of the inhibin network to assess its prognostic value in multiple solid tumors, identifying key dependencies and therapeutic implications.

Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

Pharmacological inhibition of the ALK axis elicits therapeutic potential in Consensus Molecular Subtype 1 colon cancer patients

This study shows that ALK inhibition improves outcomes in CMS1 colon cancer patients by reducing cell proliferation and enhancing cell adhesion.

RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

This study shows RIP140 inhibits breast cancer cell glycolysis and proliferation by reducing GLUT3 expression through interaction with HIF-2 and p53.

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

The paper investigates genome-wide uracil distribution changes in human cells after chemotherapy, finding drug-induced shifts toward active genomic regions.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

This study identifies FAK activity as a driver of platinum resistance in ovarian cancer by sustaining CSC survival and DNA repair, showing that FAK inhibitors combined with platinum can overcome resistance.

The orphan nuclear receptor estrogen-related receptor beta (ERRβ) in triple-negative breast cancer

This study examines the association of ESRRB mRNA, copy number, and protein expression with clinicopathological features in breast cancer specimens, finding reduced ESRRB expression and distinct isoform activity in TNBC/BLBC.

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.

SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer

This study identifies SREBP1-driven KRT80 upregulation as a mechanism promoting invasion in endocrine-resistant ERα breast cancer through cytoskeletal changes and increased tumor stiffness.

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.

This study maps enhancers in luminal breast cancer to reveal phenotypic heterogeneity and its evolutionary dynamics during treatment.