The paper examines the role of ecological factors in maintaining a stable hybrid zone between western and glaucous-winged gulls, finding evidence of niche divergence and supporting the bounded superiority model.

bioRxiv · Dec 14, 2023 · PreprintEcology

Turnover of retroelements and satellite DNA drives centromere reorganizationover short evolutionary timescales in Drosophila

C. Courret, L. Hemmer, X. Wei, P. D. Patel, B. Chabot, N. J. Fuda, X. Geng, C.-H. Chang, B. Mellone, A. M. Larracuente

The paper investigates centromere reorganization in Drosophila species, finding rapid turnover of retroelements and satellite DNA over short evolutionary timescales.

bioRxiv · Aug 22, 2023Evolutionary Biology

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

C. Su, Y. Wen, X. Geng, C. Yang, Q. Yin, Y. Xiong, Z. Liu

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

bioRxiv · Apr 23, 2023 · PreprintImmunology

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

J. Ye, X. Ye, W. Jiang, C. Lu, X. Geng, C. Zhao, Y. Ma, P. Yang, S. M. Lam, G. Shui, T. Yang, J. Z. Li, Y. Gong, Z. Fu, H. Zhou

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

bioRxiv · Oct 23, 2020Physiology

Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPARG dependent manner

H. Yang, M. Xu, X. Wang, X. Jia, Y. Li, X. Geng, L. Zhang

This study shows arachidonic acid metabolism regulates macrophage polarization by affecting oxidative phosphorylation through PPARG, influencing M1 and M2 macrophage activation.

bioRxiv · Oct 15, 2020Immunology

The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods

Z. Wang, J. Xu, J. Mou, X. Zhao, X. Geng, M. Wu, H. Xue, L. Chen, L. Xu

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

bioRxiv · May 26, 2020Cell Biology

The orphan nuclear receptor estrogen-related receptor beta (ERRβ) in triple-negative breast cancer

A. I. Fernandez, X. Geng, K. Chaldekas, B. Harris, A. Duttargi, V. L. Berry, D. L. Berry, A. Mahajan, L. R. Cavalli, B. Gyorffy, M. Tan, R. B. Riggins

This study examines the association of ESRRB mRNA, copy number, and protein expression with clinicopathological features in breast cancer specimens, finding reduced ESRRB expression and distinct isoform activity in TNBC/BLBC.

bioRxiv · Aug 13, 2019Cancer Biology

Bifunctional enzyme SpoT is involved in biofilm formation of Helicobacter pylori with multidrug resistance by upregulating efflux pump Hp1174 (gluP)

Y. Sun, X. Ge, Y. Cai, Z. Chen, S. Gao, X. Geng, Y. Li, Y. Li, J. Jia

bioRxiv · May 13, 2018Microbiology