M. Tan

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Cellular and molecular characterization of peripheral glia in the lung and other organs

This study characterizes peripheral glia in the lung and other organs using scRNA-seq, identifying molecularly distinct populations and conserved gene expression across species.

A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer

This paper demonstrates that the engineered lectin H84T binds to and inhibits NSCLC cell growth by lysosomal degradation of EGFR, independent of EGFR mutation status.

Exploring information exchange between Thesium chinense and its host Prunella vulgaris through joint transcriptomic and metabolomic analysis

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.

Twilight length alters growth, flowering time, and clock function in Arabidopsis via LHY/CCA1

This study shows that twilight length affects Arabidopsis growth, flowering time, and circadian clock function through the LHY/CCA1 pathway.

Background matching can reduce responsiveness of jumping spiders to stimuli in motion

This study shows that jumping spiders are less responsive to camouflaged moving stimuli than to conspicuous ones, with smaller and faster stimuli being less detectable.

Zebrafish embryos are more efficient and robust than zebrafish larvae in evaluating human norovirus infectivity

This study shows zebrafish embryos are more efficient and robust than larvae for evaluating human norovirus infectivity, enabling virus passaging and UV inactivation testing.

Mucosal and systemic neutralizing antibodies to norovirus and rotavirus by oral immunization with recombinant rotavirus in infant mice

This paper demonstrates that oral immunization with a recombinant rotavirus expressing norovirus VP1 induces systemic and mucosal neutralizing antibodies against both rotavirus and norovirus in infant mice.

Regulation of Chlamydia RsbU phosphatase activity by the enolase product, phosphoenolpyruvate

This study identifies phosphoenolpyruvate as an inhibitor of Chlamydia RsbU phosphatase activity, linking glucose metabolism to transcriptional regulation via the RsbW pathway.

Adaptive shifts underlie the divergence in wing morphology in bombycoid moths

This study examines how adaptive shifts in wing morphology correlate with ecological and behavioral divergence in two moth families.

Quantitative proteome and PTMome analysis of Arabidopsis thaliana root responses to persistent osmotic and salinity stress.

This study analyzes proteome and PTMome changes in Arabidopsis roots under osmotic and salt stress, revealing distinct regulatory mechanisms across different proteome levels.

Fucoidan but not 2'-Fucosyllactose could inhibit human norovirus replication in zebrafish larvae

This study compares fucoidan and 2'-Fucosyllactose in inhibiting human norovirus replication in zebrafish larvae, finding only fucoidan effectively inhibits replication.

HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19

This study uses immune simulation to show that HLA class I genotypes influence the effectiveness of multi-epitope vaccination strategies against SARS-CoV-2.

Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.

Phosphate and phosphite differentially impact the proteome and phosphoproteome of Arabidopsis suspension cell cultures

The paper compares proteome and phosphoproteome responses of Arabidopsis cells to phosphate and phosphite resupply, identifying phosphorylation changes linked to phosphorus nutrition.

Rapid metagenomic characterization of a case of imported COVID-19 in Cambodia

The paper describes using metagenomic sequencing and an open-source pipeline to rapidly characterize Cambodia's first COVID-19 case.

Designing and implementing programmable depletion in sequencing libraries with DASHit

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

Stochastic analysis of optimal production of infectious progeny in Chlamydia

The paper uses stochastic optimal control models to analyze Chlamydia's life cycle and shows an initial RB-to-EB conversion holiday supports Darwinian survival.

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing

This study uses metagenomic sequencing to identify pathogens in transfusion-related sepsis cases, revealing a novel Acinetobacter species and demonstrating the utility of culture-independent methods.

The orphan nuclear receptor estrogen-related receptor beta (ERRβ) in triple-negative breast cancer

This study examines the association of ESRRB mRNA, copy number, and protein expression with clinicopathological features in breast cancer specimens, finding reduced ESRRB expression and distinct isoform activity in TNBC/BLBC.

PIWIL3 forms a complex with TDRKH in mammalian oocytes

The paper identifies PIWIL3's localization in bovine oocytes, its interaction with TDRKH and PNLDC1 in a mitochondrial complex, and its role in piRNA-mediated transposable element suppression.

Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis

This study identifies high levels of enterovirus antibodies in cerebrospinal fluid of children with acute flaccid myelitis compared to controls, suggesting a causal role for non-polio enteroviruses.

Screening and functional analysis of differentially expressed genes in an animal model of EBV-associated lymphomas

The paper identifies 202 differentially expressed genes in EBV-induced lymphomas using a mouse model and highlights key genes involved in the oncogenic process.

Molecular basis of P major human rotavirus VP8* domain interactions with histo-blood group antigens

This paper uses NMR to determine how P[8] and P[6] rotavirus VP8* domains bind to different histo-blood group antigens, revealing structural differences that may explain their distinct host ranges and evolutionary adaptations.

Tibetan antelope rests like a Puppet

The paper describes a new standing rest behavior in Tibetan antelopes called 'Puppet behavior,' observed more frequently in males and linked to thermoregulation and anti-predation.

Protein Deacetylase CobB Interplays with c-di-GMP

The paper identifies a novel negative feedback loop where c-di-GMP inhibits CobB activity, modulating acetyl-CoA biogenesis and YdeH stability and cyclase activity.