Crystal structure of the M5 muscarinic acetylcholine receptor
Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal
The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.
bioRxiv · Aug 14, 2019Pharmacology & Toxicology