S. Varghese

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.

Simulating atmospheric drought: Silica gel packets dehumidify mesocosm microclimates

This study shows silica gel packets effectively simulate atmospheric drought in mesocosms when combined with soil drought treatments, improving understanding of drought impacts on plant communities.

A multi-functional small molecule alleviates fracture pain and promotes bone healing

This study shows adenosine can reduce fracture pain and promote bone healing by targeting specific receptors in different cell types.

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis

This study identifies Mindin as a key driver of fibrosis in a new mouse model of systemic sclerosis, showing its role in inducing inflammation and collagen production in fibroblasts.

Self-healing of hyaluronic acid to improve in vivo retention and function

This study modifies hyaluronic acid to have self-healing properties, showing improved in vivo retention and cartilage protection in rodents.

Dragonfly Inspired Smart Soft Robot

This paper introduces DraBot, a dragonfly-inspired soft robot capable of locomotion, sensing, and environmental adaptation using pneumatic and microfluidic logic.

In vivo sequestration of innate small molecules to promote bone healing

This study develops a biomaterial that sequesters and delivers adenosine to enhance bone healing by promoting osteoblastogenesis and angiogenesis.

Crystal structure of the M5 muscarinic acetylcholine receptor

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.

Three-dimensional Monolayer Stress Microscopy

This paper introduces a 3D Monolayer Stress Microscopy method to measure intracellular stresses in cell monolayers, revealing distinct contributions of lateral deformation and bending.