Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
W. Burger, C. Draper-Joyce, C. Valant, A. Christopoulos, D. M. Thal
This study shows positive allosteric modulators stabilize the GPCR-G protein ternary complex, enhancing signaling when nucleotides are present.
bioRxiv · Apr 4, 2024Pharmacology & Toxicology
Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal
The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.
bioRxiv · Sep 27, 2022Pharmacology & Toxicology
J. Mobbs, M. J. Belousoff, K. G. Harikumar, S. J. Piper, X. Xu, S. G. B. Furness, H. Venugopal, A. Christopoulos, R. Danev, D. Wootten, D. M. Thal, L. J. Miller, P. M. Sexton
The paper determines cryo-EM structures of the CCK1R bound to Gs and Gq proteins, revealing conformational changes that enable promiscuous G protein coupling.
bioRxiv · May 6, 2021Pharmacology & Toxicology
G. Deganutti, Y.-L. Liang, X. Zhang, M. Khoshouei, L. Clydesdale, M. J. Belousoff, H. Venugopal, T. T. Truong, A. Glukhova, A. N. Keller, K. J. Gregory, K. Leach, A. Christopoulos, R. Danev, C. A. Reynolds, , D. M. Wootten
The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.
bioRxiv · Mar 10, 2021Biochemistry
J. Rae, C. Ferguson, N. Ariotti, R. Webb, H.-H. Cheng, J. Mead, J. Riches, D. Hunter, N. Martel, J. Baltos, A. Christopoulos, N. Bryce, M. Cagigas, S. Fonseka, E. Hardeman, , R. G. Parton
APEX-Gold converts APEX reaction products into silver/gold particles for improved EM detection of tagged proteins.
bioRxiv · Oct 6, 2020 · PreprintCell Biology
X. Zhang, M. J. Belousoff, P. Zhao, A. J. Kooistra, T. T. Truong, S. Y. Ang, C. R. Underwood, T. Egebjerg, P. Senel, G. D. Stewart, Y.-L. Liang, A. Glukhova, H. Venugopal, A. Christopoulos, S. G. Furness, , D. Wootten
The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.
bioRxiv · Aug 16, 2020Pharmacology & Toxicology
P. Rueda, J. Merlin, S. Chimenti, M. Feletou, J. Paysant, P. J. White, A. Christopoulos, P. M. Sexton, R. J. Summers, W. N. Charman, L. T. May, C. J. Langmead
This study compares the safety and efficacy of A1R agonists, showing that biased agonism away from Ca2+ influx relative to cAMP improves safety but may not guarantee efficacy in heart failure.
bioRxiv · Jul 22, 2020Pharmacology & Toxicology
Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal
The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.
bioRxiv · Aug 14, 2019Pharmacology & Toxicology