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9 papers
Recent·Most cited
H. P. Savage, D. J. Bays, M. A. F. Gonzalez, E. J. Bejarano, H. Nguyen, H. L. P. Masson, T. P. Carvalho, R. L. Santos, G. Thompson, A. J. Bäumler
This study shows that 5-ASA can replace Clostridia to prevent Candida albicans overgrowth by restoring epithelial hypoxia after antibiotic treatment.
bioRxiv · Apr 17, 2023 · PreprintMicrobiology
Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal
The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.
bioRxiv · Sep 27, 2022Pharmacology & Toxicology
R. de la Cerda, G. Thompson, P. Zhang, K. Hokamp, F. Roche, S. Carlin, U. Vrhovsek, U. M. Bond
This study enhances flavour profiles in S. pastorianus lager yeast by inducing genomic variation through radicicol-mediated aneuploidy and selection for aromatic amino acid production.
bioRxiv · May 17, 2022 · PreprintMicrobiology
J. A. Garcia, K. Vu, G. Thompson, A. Gelli
This study characterizes a Coccidioides posadasii strain that maintains parasitic morphology at ambient CO2 and shows hyphal growth under spherule-inducing conditions.
bioRxiv · Mar 29, 2022Microbiology
S. Meek, T. Watson, L. Eory, G. McFarlane, F. J. Wynne, S. McCleary, L. E. M. Dunn, E. M. Charlton, C. Craig, B. Shih, T. Regan, R. M. Taylor, L. Sutherland, A. Gossner, C. Chintoan-Uta, , T. Burdon
The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.
bioRxiv · Sep 10, 2021Immunology
D. Cantoni, A. O. Osborne, N. Taib, G. Thompson, E. Kazana, E. Edrich, I. R. Brown, S. Gribaldo, C. Gourlay, A. Tsaousis
The paper characterizes the localization and function of alternative oxidase in Naegleria species, showing its role in proliferation and potential pathogenicity.
bioRxiv · Sep 26, 2020 · PreprintMicrobiology
Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal
The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.
bioRxiv · Aug 14, 2019Pharmacology & Toxicology
M. M. Teixeira, P. Alvarado, C. Roe, G. Thompson, J. S. L. Patane, J. W. Sahl, P. Keim, J. N. Galgiani, A. P. Litvintseva, D. R. Matute, B. M. Barker
The paper identifies strong population structure and genetic differentiation in Coccidioides posadasii from Venezuela compared to North American populations, with evidence of admixture in Central America.
bioRxiv · Jul 30, 2019 · PreprintEvolutionary Biology
A. Park, T. Tran, E. Scheuermann, L. Gutierrez, C. Stojanik, J. Plyler, G. Thompson, D. Smith, N. S. Atkinson
The paper identifies two pathways by which alcohol increases aggression in male flies: one through enhancing an olfactory pheromone and the other through systemic alcohol effects.
bioRxiv · Jun 27, 2019 · PreprintEcology