Cancer BiologybioRxiv
Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors
A. Henssen, R. Koche, J. Zhuang…·A. Kentsis
This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.
DOI 10.1038/ng.3866