Author

A. F. Garretson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

S. L. Leibel· 3 shared A. E. Clark· 2 shared A. F. Carlin· 2 shared A. G. Schmidt· 2 shared A. Narayanan· 2 shared C. B. Spliid· 2 shared D. R. Sandoval· 2 shared G. J. Golden· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

S. L. Leibel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs

R. T. Schooley, A. F. Carlin, J. R. Beadle, N. Valiaeva, X.-Q. Zhang, A. E. Clark, R. E. McMillian, S. L. Leibel, R. N. McVicar, J. Xie, A. F. Garretson, V. I. Smith, J. A. Murphy, K. Y. Hostetler

This paper develops orally bioavailable lipid prodrugs of Remdesivir that show submicromolar anti-SARS-CoV-2 activity and therapeutic plasma levels in Syrian hamsters.

Antimicrobial Agents and Chemotherapy · Sep 17, 2021Peer-reviewedMicrobiology

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

D. R. Sandoval, T. Mandel Clausen, C. Nora, J. A. Magida, A. P. Cribbs, A. Denardo, A. E. Clark, A. F. Garretson, J. K. C. Coker, A. Narayanan, S. A. Majowicz, M. Philpott, C. Johansson, J. E. Dunford, C. B. Spliid, , Mazitsch

This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

T. M. Clausen, D. R. Sandoval, C. B. Spliid, J. Pihl, C. D. Painter, B. E. Thacker, C. A. Glass, A. Narayanan, S. A. Majowicz, Y. Zhang, J. L. Torres, G. J. Golden, R. Porell, A. F. Garretson, L. Laubach, , J. D. Esko

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

Cell · Nov 1, 2020Peer-reviewedMicrobiology