MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewed
Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs
R. T. Schooley, A. F. Carlin, J. R. Beadle…·K. Y. Hostetler
This paper develops orally bioavailable lipid prodrugs of Remdesivir that show submicromolar anti-SARS-CoV-2 activity and therapeutic plasma levels in Syrian hamsters.
DOI 10.1128/aac.01155-21