A. Narayanan

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

Thermal adaptation of soil microbial growth traits in response to chronic warming

This study examines how long-term soil warming affects bacterial growth traits, finding increased optimum growth temperatures but no changes in temperature sensitivity or maximum growth temperatures.

Pangenomes reveal genomic signatures of microbial adaptation to experimental soil warming

The paper uses pangenomics to identify genomic signatures of microbial adaptation to experimental soil warming.

Asymmetric oligomerization state and sequence patterning can tune multiphase condensate miscibility

This study shows that increasing the oligomerization state of intrinsically disordered proteins enhances immiscibility and multiphase formation in biomolecular condensates.

DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Response

This study shows that DNA origami nanoparticles displaying SARS-CoV-2 RBD trimers and CpG adjuvants induce strong protective immunity in mice.

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy

This study shows that Numb-associated kinases are essential for SARS-CoV-2 infection and that inhibiting them can suppress viral infection in human lung cells.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

This study identifies TRIM67 as an oncogene in oligodendrogliomas that promotes cell motility, tumor growth, and membrane blebbing through Rho GTPase/ROCK signaling.

A condensate dynamic instability orchestrates oocyte actomyosin cortex activation

The paper identifies a dynamic instability in protein condensates that drives actomyosin cortex activation in C. elegans oocytes.

MEOX2 homeobox gene promotes growth of malignant gliomas

This study identifies MEOX2 as an oncogenic transcription factor in glioblastoma, showing it promotes tumor growth through ERK signaling and cooperates with p53 and PTEN loss.

Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women

This study identifies elevated antiviral cytokines, immunoglobulins, and specific immune cell subsets in HESN women, along with increased bacterial diversity and Gardnerella spp abundance in the cervicovaginal microbiome, suggesting protective mechanisms against HIV.

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.

Development of a novel hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening and quantification of neutralization antibodies, viral variants, and antiviral drugs

This paper develops a hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening of neutralizing antibodies, viral variants, and antiviral drugs, showing increased infectivity of variants and enhanced neutralization by post-vaccination serum.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

Brilacidin, a COVID-19 Drug Candidate, Exhibits Potent In Vitro Antiviral Activity Against SARS-CoV-2

This paper shows brilacidin, a synthetic small molecule, strongly inhibits SARS-CoV-2 in cell cultures and works well with remdesivir.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

Wild flies hedge their thermal preference bets in response to seasonal fluctuations

The paper tests if thermal preference variation in Drosophila melanogaster reflects a bet-hedging strategy across regions and finds evidence supporting this evolutionary strategy.

Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture

This study identifies four FDA-approved drugs that inhibit SARS-CoV-2 infection in cell culture, with Maraviroc showing reduced S-protein mediated cell fusion.

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

This study uses single-cell RNA sequencing to analyze the host and viral RNA dynamics during VEEV infection, identifying superproducer cells and candidate antiviral targets.