Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.
A. B. Lanne, Y. Cui, E. Browne, P. G. E. Craven, N. J. Cundy, N. J. Coltman, K. Dale, A. Feula, J. Frampton, A. Goff, M. A. Hama Salih, X. Lang, X. Li, C. W. Moon, M. Morton, , L. J. Alderwick
The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.
bioRxiv · Sep 3, 2020 · PreprintMicrobiology