C. Wang

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions

This study identifies the kinase KEY1 as a regulator of pyrenoid condensate size and dynamics in Chlamydomonas reinhardtii, showing it disrupts phase separation interactions to control condensate dissolution during the cell cycle.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Epigenetic Dynamics in Meniscus Cell Migration and its Zonal Dependency in Response to Inflammatory Conditions: Implications for Regeneration Strategies

This study investigates how epigenetic mechanisms regulate meniscus cell migration under inflammation, revealing zonal differences and potential therapeutic targets.

DdmDE eliminates plasmid invasion by DNA-guided DNA targeting

This study elucidates the mechanism of the DdmDE system in eliminating plasmids through DNA-guided targeting and cleavage.

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Synchronous assembly of peptide anisosome

This study reports the formation of symmetrical core-shell biomolecular condensates through programmed tetra-peptide libraries and identifies tryptophan's role in structuring these condensates.

INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement

This study shows INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement through high-resolution imaging and genetic manipulation.

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk

This study identifies that TLR9 activation requires phosphorylation of two specific tyrosine residues by EGFR and Syk, which is critical for downstream signaling.

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

The paper identifies a Pseudomonas aeruginosa VgrG2b fragment cleaved by caspase-11 that inhibits NLRP3 inflammasome activation, promoting infection and improving survival with a specific peptide inhibitor.

Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

TurboID-mediated surface protein biotinylation to inhibit the growth of Staphylococcus aureus

This study uses TurboID-mediated biotinylation of surface proteins to inhibit the growth and virulence of multiple S. aureus strains.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/BNIP3L-dependent mitophagy

High IL-1β and IL-18 Levels Associate with Gut Barrier Disruption and Monocyte Activation During Chronic SIV Infection with Long-Term Suppressive Antiretroviral Therapy

This study links elevated IL-1β and IL-18 levels with gut barrier disruption and monocyte activation in SIV-infected macaques on long-term ART, suggesting a role in CVD and metabolic complications.

Embracing Uncertainty Reshapes the ETHYLENE INSENSITIVE2-Activated Ethylene Signaling Framework

The paper challenges the current model of ethylene signaling by showing EIN2 activation can occur independently of CTR1, ETP1/ETP2, and MHL1/MHL2, and reveals new interactions and regulatory mechanisms.

Contracted anterior-posterior systematic covariance of cortical thickness in early-onset schizophrenia

This study identifies a contracted anterior-posterior organizational axis of cortical thickness in early-onset schizophrenia using structural MRI data.

Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at post-transcriptional level

This study identifies B11, a conserved mycobacterial sRNA, as a post-transcriptional regulator of lipooligosaccharide synthesis, revealing its mechanism of action through RNA-seq and mass spectrometry.

Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

This study designs and synthesizes functional fluorophores using a scaffold-based Ugi reaction, enabling detection of reactive-oxygen species and controlled subcellular localization, with some compounds showing pyroptosis-inducing activity in cancer cells.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Insecticide resistance and its intensity in urban Anopheles arabiensis in Kisumu City, Western Kenya: Implications for malaria control in urban areas

This study assesses insecticide resistance in urban Anopheles arabiensis in Kisumu City, Kenya, finding high resistance to pyrethroids and elevated detoxification enzyme levels.

Recombinant expression, purification, and antifungal activity of the novel antimicrobial peptide TaW662

This study identifies and characterizes TaW662, an antifungal peptide from wheat, showing inhibition of Blumeria graminis f. sp. tritici growth and potential as a fungicide.

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Similar, but not the same: multi-omics comparison of human valve interstitial cells and osteoblast osteogenic differentiation expanded with an estimation of data-dependent and data-independent PASEF

The paper compares proteomic and transcriptomic profiles of valve interstitial cells and osteoblasts during osteogenic differentiation, identifying potential therapeutic targets for calcific aortic valve disease.

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

This paper engineers Escherichia coli Nissle 1917 to block antibiotic resistance gene transfer using a type I CRISPR-Cas system, showing efficacy in vitro and in zebrafish.

Matrimeres are systemic nanoscale mediators of tissue integrity and function

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

Novel Ser74 of NF-kappaB/CgIkappaBalpha Phosphorylated by MAPK/ERK Regulates Temperature Adaptation in Oysters

The paper identifies a novel phosphorylation site (Ser74) in oyster NF-kappaB/CgI{kappa}B regulated by MAPK/ERK that mediates thermal adaptation through ubiquitin-proteasome degradation and nuclear translocation of CgREL.