Author

J. Frampton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. S. Walton· 2 shared G. Volpe· 2 shared M. L. Clarke· 2 shared A. B. Lanne· 1 shared A. Feula· 1 shared A. Goff· 1 shared A. Yoshizawa· 1 shared B. Noyvert· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

D. S. Walton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MYB insufficiency disrupts proteostasis in hematopoietic stem cells leading to age-related neoplasia

M. L. Clarke, R. B. Lemma, D. S. Walton, G. Volpe, B. Noyvert, O. S. Gabrielsen, J. Frampton

This study shows that Myb insufficiency in mice leads to age-related hematological diseases, suggesting proteostasis disruption as a mechanism.

bioRxiv · Sep 4, 2021Cancer Biology

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.

A. B. Lanne, Y. Cui, E. Browne, P. G. E. Craven, N. J. Cundy, N. J. Coltman, K. Dale, A. Feula, J. Frampton, A. Goff, M. A. Hama Salih, X. Lang, X. Li, C. W. Moon, M. Morton, , L. J. Alderwick

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology

Ablation of MYB-dependent leukaemia phenotype in MLL-driven AML correlates with increased expression of MAFB.

C. Ward, P. Cauchy, D. S. Walton, M. L. Clarke, D. Blakemore, F. Grebien, P. Garcia, J. Frampton, G. Volpe

The paper shows that MYB ablation in MLL-driven AML increases MAFB expression, while this effect is absent in AML with complex karyotypes.

bioRxiv · May 27, 2020 · PreprintCancer Biology