Author

A. Florentin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

V. Muralidharan· 6 shared D. W. Cobb· 4 shared M. A. Fierro· 3 shared H. M. Kudyba· 2 shared M. Krakowiak· 2 shared A. L. Valenciano· 1 shared B. Singh· 1 shared B. Striepen· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersMicrobiology

V. Muralidharan

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6 papers

Recent·Most cited

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

F. M. Zimbres, A. L. Valenciano, E. F. Merino, N. R. Holderman, A. Florentin, G. He, K. Gawarecka, K. Skorupinska-Tudek, M. L. Fernandez-Murga, E. Swiezewska, X. Wang, V. Muralidharan, M. B. Cassera

This study uses metabolomics to show that Plasmodium falciparum has diverse and active cis-polyisoprenoid biosynthesis, including polyprenols and dolichols, with functional substitution potential.

bioRxiv · Mar 18, 2020Biochemistry

The Clp System in Malaria Parasites Degrades Essential Substrates to Regulate Plastid Biogenesis

A. Florentin, D. R. Stephens, C. F. Brooks, R. P. Baptista, V. Muralidharan

This study identifies the role of the Clp protease system in regulating apicoplast biogenesis in Plasmodium falciparum by demonstrating its enzymatic activity and interactions with chaperones and substrates.

bioRxiv · Nov 4, 2019Microbiology

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.

H. M. Kudyba, D. W. Cobb, M. A. Fierro, A. Florentin, D. Ljolje, B. Singh, N. W. Lucchi, V. Muralidharan

This study identifies PfGRP170 as an essential ER chaperone in Plasmodium falciparum, critical for asexual development and stress response.

bioRxiv · Apr 17, 2019Cell Biology

CRISPR/Cas9 gene editing to make conditional mutants of the human malaria parasite Plasmodium falciparum

H. M. Kudyba, D. W. Cobb, A. Florentin, M. Krakowiak, V. Muralidharan

This paper describes a CRISPR/Cas9 method for generating conditional knockdown mutants in Plasmodium falciparum, enabling genetic manipulation of the malaria parasite.

bioRxiv · May 15, 2018Cell Biology

The exported chaperone PfHsp70x is dispensable for the Plasmodium falciparum intraerythrocytic lifecycle

D. W. Cobb, A. Florentin, M. A. Fierro, M. Krakowiak, J. M. Moore, V. Muralidharan

This study shows that PfHsp70x, the sole exported Hsp70 in P. falciparum, is not essential for parasite growth or protein export during the intraerythrocytic lifecycle.

bioRxiv · Aug 11, 2017Microbiology

PfClpC Is An Essential Clp Chaperone Required For Plastid Integrity And Clp Protease Stability In Plasmodium falciparum

A. Florentin, D. W. Cobb, J. D. Fishburn, M. J. Cipriano, P. S. Kim, M. A. Fierro, B. Striepen, V. Muralidharan

This paper identifies PfClpC as an essential apicoplast-targeted chaperone in Plasmodium falciparum, showing its role in maintaining apicoplast integrity and parasite viability.

bioRxiv · Jun 20, 2017Microbiology