G. He

Rapid wing size evolution in African fig flies (Zaprionus indianus) following temperate colonization

This study shows Zaprionus indianus evolves smaller wings after colonizing temperate regions, suggesting rapid adaptation to new environments.

Multi-omics analysis of a traditional fermented food reveals a byproduct-associated subpopulation of Neurospora intermedia for waste-to-food upcycling

This study uses multi-omics analysis to characterize Neurospora intermedia in oncom, revealing its role in byproduct conversion and potential for waste-to-food upcycling.

A new group of LysM-RLKs involved in symbiotic signal perception and arbuscular mycorrhiza establishment

The paper identifies a new group of LysM-RLK receptors that bind both LCO and CO, playing a complementary role with LYR-IA receptors in arbuscular mycorrhiza formation.

pH selects for distinct N2O-reducing microbiomes in tropical soil microcosms

This study investigates N2O reduction in acidic tropical soils, finding distinct microbial communities and novel taxa associated with N2O reduction at low pH.

Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling

This paper introduces copepodTCR, a tool for designing and interpreting TCR specificity assays, which efficiently identifies antigen-specific TCRs using combinatorial peptide pooling and Bayesian modeling.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Sustained bacterial (N2O) reduction at acidic pH

The paper identifies a bacterial culture from acidic soil that reduces N2O to N2 at pH 4.5, challenging the assumption that microbial N2O reduction is limited to circumneutral pH.

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1

This study develops an ex vivo CRISPR gene editing protocol for hepatocytes to treat hereditary tyrosinemia type 1, showing successful engraftment and disease correction in mice.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

A bi-kinase module sensitizes and potentiates plant immune signaling

The paper identifies a Ca2+ sensing bi-kinase module that enhances NADPH oxidase activation through mutual trans-phosphorylation, enabling systemic immunity in plants.

Seagrass genomes reveal a hexaploid ancestry facilitating adaptation to the marine environment

This study presents chromosome-level genome assemblies of seagrass species and identifies ancient and recent genome duplication events linked to adaptation to marine environments.

Phase-separating pyrenoid proteins form complexes in the dilute phase

The paper demonstrates the existence of protein complexes in the dilute phase of phase-separating systems using an algal pyrenoid reconstitution system and fluorescence correlation spectroscopy.

The western redcedar genome reveals low genetic diversity in a self-compatible conifer

The paper assembles the western redcedar genome and finds it has low genetic diversity, suggesting mechanisms like associative overdominance maintain genetic variation despite selfing.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Co-cultivation of the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii enhances transcription of carbohydrate binding modules

This study shows that co-culturing the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii increases transcription of carbohydrate binding modules and related enzymes, enhancing biomass breakdown and sugar uptake.

Evolutionary priming and transition to the ectomycorrhizal habit in an iconic lineage of mushroom-forming fungi: is preadaptation a requirement?

This study identifies genomic features of the transition to ectomycorrhizal habit in Russulaceae fungi, finding gene loss, TE expansion, and secreted protein associations with TE nests.

A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

The paper identifies a selective sweep in the Spike gene of SARS-CoV-2 that enhanced human adaptation by improving binding to human ACE2 and replication in human cells.

Identification of enzymes for lignocellulose degradation in the genome and transcriptome of the aquatic hyphomycete Clavariopsis aquatica.

The paper identifies enzymes for lignocellulose degradation in Clavariopsis aquatica by analyzing its genome and transcriptome under different substrates.

Quantify the requirements to achieve grain Zn biofortification of high-yield wheat on calcareous soils

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

This study uses metabolomics to show that Plasmodium falciparum has diverse and active cis-polyisoprenoid biosynthesis, including polyprenols and dolichols, with functional substitution potential.

The kinetochore protein Spc105, a novel interaction partner of LaeA, regulates development and secondary metabolism in Aspergillus flavus

This paper identifies Spc105 as a new LaeA interaction partner in Aspergillus flavus, showing its role in development, secondary metabolism, and regulatory interdependence with LaeA.

CRISPR/Cas9-mediated resistance to cauliflower mosaic virus

This study shows CRISPR-Cas9 can confer resistance to cauliflower mosaic virus by targeting coat protein sequences, leading to non-functional viral proteins and reduced infection.