RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma
S. K. Kailasam Mani, Z. Cui, B. Yan, S. Utturkar, A. Foca, N. Fares, D. Durantel, N. Lanman, P. Merle, M. Kazemian, O. Andrisani
This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.
bioRxiv · Sep 12, 2019 · PreprintCancer Biology