B. Yan

An Artificial Intelligence-Assisted Digital Microfluidic System for Multistate Droplet Control

This paper introduces an AI-assisted digital microfluidic system called DropAI for multistate droplet control using semantic segmentation and state machine feedback.

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

A chemical molecule promotes Trop2+ biliary duct organoids differentiation into insulin-secreting cells

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.

Survival mechanism of a novel marine multistress-tolerant Meyerozyma guilliermondii GXDK6 under high NaCl stress as revealed by integrative omics analysis

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

Emergence of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Co-harbouring a blaNDM-1-carrying Virulent Plasmid and a blaKPC-2-carrying Plasmid in an Egyptian Hospital

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

Effects of carbon, nitrogen, phosphorus, and potassium on flowering and Fruiting of Glycyrrhiza uralensis

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

Gut microbiome couples gut and brain during calorie restriction in treating obesity

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

Oxidoreductases generate hydrogen peroxide that drives iron-dependent lipid peroxidation during ferroptosis

This study identifies POR and CYB5R1 as oxidoreductases that generate hydrogen peroxide, driving iron-dependent lipid peroxidation and ferroptosis.

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

Sclerotinia sclerotiorum hijacks copper from its host for infection

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

HPV-positive head and neck cancer derived exosomal miR-9 induces M1 macrophage polarization and increases tumor radiosensitivity

This study shows HPV+ HNSCC exosomes containing miR-9 polarize macrophages to M1, increasing tumor radiosensitivity.

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.

Mesenchymal stem cells protect retinal ganglion cells from degeneration via mitochondrial donation

This study shows that mesenchymal stem cells (MSCs) protect retinal ganglion cells (RGCs) from degeneration by donating mitochondria, reducing inflammation, and preserving retinal function in a mouse model.