M. Kazemian

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

This study shows PBRM1 regulates stress response and apoptosis in epithelial cells by affecting reactive oxygen species and cell viability.