Z. Cui

Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells enhance migration and regulate gene expression of reparative mechanisms in human dermal fibroblasts

This study compares the effects of sEV and NsEV fractions from hBM-MSCs and NHDFs on fibroblast migration and gene expression, finding sEVs more effective in promoting migration.

Programming aliphatic polyester degradation by engineered bacterial spores

This paper demonstrates engineered bacterial spores displaying enzymes for sustainable aliphatic polyester degradation, showing repeated reuse and full activity recovery.

Elucidation of chalkophomycin biosynthesis reveals N-hydroxypyrrole-forming enzymes

The paper identifies and characterizes enzymes involved in N-hydroxypyrrole biosynthesis, revealing new insights into the formation of unique functional groups in natural products.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

This paper demonstrates the feasibility of intranasally delivering monoclonal antibodies as dry powders using thin-film freeze-drying and the UDS Powder Nasal Spray System.

Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

Pontiella agarivorans sp. nov., a novel marine anaerobic bacterium capable of degrading macroalgal polysaccharides and fixing nitrogen

Impact of inter-species interactions between flower microbiota commensals and a floral pathogen on disease incidence and pathogen activity

The paper investigates how interactions between flower microbiota commensals and a floral pathogen affect disease incidence and pathogen activity through field and in vitro experiments.

MicroRNA-195-3p as a potential regulator of hypoxic injury in HUVECs

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive AS01B-adjuvanted vaccine powders

This study demonstrates that thin-film freeze-drying can convert a liquid vaccine into a dry powder with mucoadhesive properties, which can be effectively delivered using a nasal device for intranasal vaccination.

SARS-CoV-2 infected cells sprout actin-rich filopodia that facilitate viral invasion

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

Aerosolizable plasmid DNA dry powders engineered by thin-film freezing

This study tests thin-film freezing to create aerosolizable plasmid DNA dry powders for pulmonary delivery, finding good aerosol performance and preserved pDNA integrity.

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB

This paper determines the structural basis of mTORC1-dependent phosphorylation of TFEB using cryo-EM, revealing how TFEB is presented to mTORC1 for phosphorylation through a unique RagC GDP-dependent mechanism.

Accelerated mass transfer from frozen thin films during thin-film freeze-drying

This study demonstrates that thin-film freeze-drying (TFFD) significantly accelerates mass transfer compared to conventional freeze-drying, preserving bacterial viability and enabling efficient powder production.

Development of Dry Powder Formulations of AS01B containing vaccines using Thin-Film Freeze-Drying

This study demonstrates that thin-film freeze-drying can produce freezing-insensitive dry powders of AS01B-adjuvanted vaccines without compromising liposome integrity or immunogenicity.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Degradation of lactoferrin caused by droplet atomization process via two fluid nozzle: The detrimental effect of air water interfaces

This study investigates how the droplet atomization process in spray freeze-drying affects lactoferrin stability, finding that high air-water interfaces cause conformational changes and aggregation.

Dry Powders for Inhalation Containing Monoclonal Antibodies Made by Thin-Film Freeze-Drying

This paper demonstrates that thin-film freeze-drying produces stable aerosolizable dry powders of monoclonal antibodies for pulmonary delivery.

Formulation of Dry Powders of Vaccines Containing MF59 or AddaVax by Thin-Film Freeze-Drying

This study demonstrates that thin-film freeze-drying can convert MF59 or AddaVax-adjuvanted vaccines into dry powders while preserving immunogenicity and stability.

AUG-3387, a Human-Derived Monoclonal Antibody Neutralizes SARS-CoV-2 Variants and Reduces Viral Load from Therapeutic Treatment of Hamsters In Vivo

AUG-3387, a human monoclonal antibody, neutralizes SARS-CoV-2 variants and reduces viral load in hamsters when administered as a dry powder inhaler formulation.

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

Thin-Film Freeze-Drying of a Norovirus Vaccine Candidate

This study demonstrates that thin-film freeze-drying can convert a Norovirus vaccine into a stable dry powder without antigen loss, enabling cold chain elimination.

The Impact of a Dynamic Working Environment on Human Gut Microbiota

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

Analysis of Spleen Histopathology, Splenocyte composition and Hematological Parameters in Mice Infected with Plasmodium berghei K173

This study examines splenomegaly, histopathology, and splenocyte composition in mice infected with Plasmodium berghei K173, showing strain-specific differences in parasite control and splenic function.

Intranasal administration of SARS-CoV-2 neutralizing human antibody prevents infection in mice

A Fc-modified human antibody prevents SARS-CoV-2 viral infection via nasal administration.

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range

This paper characterizes bacteriophage JD419, which has a broad host range and retains lytic activity under various conditions, and reports its genome lacking virulence or antibiotic resistance genes.

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.