D. Durantel

Deciphering the phospho-signature induced by hepatitis B virus in primary human hepatocytes

This study identifies phosphorylation changes in host proteins induced by HBV infection in primary human hepatocytes, revealing an intrinsic anti-viral response involving DNA repair and RNA-binding proteins.

Molecular elucidation of drug-induced abnormal assemblies of the Hepatitis B Virus capsid protein by solid-state NMR

This study uses solid-state NMR to elucidate the molecular structure of drug-induced aberrant HBV capsid assemblies and reveals differences in capsid-RNA interactions and phosphorylation between in-cell and in vitro conditions.

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production

This study identifies SRSF10 as a host RNA-binding protein that restricts HBV RNA production by interacting with the HBV core protein in the nucleus of infected hepatocytes.

Peripheral Natural Killer cells from chronic hepatitis B patients display molecular hallmarks of T cell exhaustion

The paper identifies molecular similarities between NK cells from chronic hepatitis B patients and exhausted T cells, highlighting shared pathways like TOX and NFAT in their dysfunction.

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.