Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence
A. Fukui, Y. Maruzuru, S. Ohno, M. Nobe, S. Iwata, K. Takeshima, N. Koyanagi, A. Kato, S. Kitazume, Y. Yamaguchi, Y. Kawaguchi
This study identifies an N-glycan shield on HSV-1 gB that mediates evasion from human antibodies in vivo and contributes to neurovirulence.
bioRxiv · Dec 12, 2022Microbiology