Author

A. Fumagalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. van Rheenen· 2 shared O. J. Sansom· 2 shared A. Balwierz· 1 shared A. Gusinac· 1 shared A. Krotenberg Garcia· 1 shared A. Sacchetti· 1 shared A. van Oudenaarden· 1 shared B. van der Steen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

J. van Rheenen

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Author profile →

3 papers

Recent·Most cited

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC.

M. Ganpat, F. Morales-Rodriguez, N. Pham, P. Lijnzaad, T. de Souza, S. Derakhshan, A. Fumagalli, P. Zeller, A. Balwierz, D. Ayyildiz, M. M. van den Heuvel-Eibrink, R. R. de Krijger, A. van Oudenaarden, T. Margaritis, S. M. Chuva de Sousa Lopes, J. Drost

This study creates an engineered tumor organoid model of tRCC using SFPQ-TFE3 fusion expression, revealing epithelium-to-mesenchymal differentiation and Wnt signaling involvement in tumor transformation.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

Active elimination of intestinal cells drives oncogenic growth in organoids

A. Krotenberg Garcia, A. Fumagalli, H. Quang Le, O. J. Sansom, J. van Rheenen, S. J. Suijkerbuijk

The paper shows cancer cells in organoids eliminate wild-type cells through apoptosis and JNK signaling, promoting their own growth by forcing cell death and fate change in competing cells.

bioRxiv · Nov 14, 2020Cancer Biology

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

bioRxiv · Jul 24, 2020Cancer Biology