Author

A. Sacchetti

Erasmus MC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Developmental Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. van der Steen· 2 shared M. Doukas· 2 shared R. Fodde· 2 shared R. Joosten· 2 shared A. Antanaviciute· 1 shared A. Fumagalli· 1 shared A. Gusinac· 1 shared A. Moschella· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

B. van der Steen

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Author profile →

5 papers

Recent·Most cited

Time-resolved single-cell state tracing exposes bidirectional state dynamics during differentiation

Erlantz Gonzalez Sanchez, Federica Fabro, Jonathan Klavert, Gerjanne Vroeg in de Wei, Joachim Boers, Beatrice F. Tan, A. Sacchetti, M. van Leeuwen, Eric Bindels, Ruben Boers, Joost H. Gribnau, Menno P. Creyghton

The paper uses single-cell state tracing to show bidirectional differentiation dynamics and rare transcriptome conversions across lineage boundaries in both in vivo and in vitro settings.

bioRxiv · Sep 22, 2026 · PreprintDevelopmental Biology

Membrane cliffs are giant, recursive platforms that drive calcium and protein kinase signaling for cell growth

M. Trerotola, V. Relli, R. Tripaldi, P. Simeone, E. Guerra, A. Sacchetti, M. Ceci, L. Pantalone, P. Ciufici, A. Moschella, V. Caiolfa, M. Zamai, S. Alberti

The paper identifies membrane cliffs as signaling platforms that drive calcium and kinase signaling for cell growth through Trop-2 super-complexes.

bioRxiv · Jan 8, 2024 · PreprintCell Biology

The origin of intestinal cancer in the context of inflammation

M. P. Verhagen, R. Joosten, M. Schmitt, N. Valimaki, A. Sacchetti, K. Rajamaki, J. Choi, P. Procopio, S. Silva, B. van der Steen, T. P. P. van den Bosch, D. Seinstra, M. Doukas, L. H. Augenlicht, L. A. Aaltonen, R. Fodde

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

J. D. Windster, L. E. Kuil, N. J. M. Kakiailatu, A. Antanaviciute, A. Sacchetti, K. C. MacKenzie, J. Peulen-Zink, T. W. Kan, E. Bindels, E. de Pater, M. Doukas, S. Yousefi, T. S. Barakat, C. J. H. M. Meeussen, P. C. E. J. Sloots, , M. Alves

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

bioRxiv · Sep 26, 2023Pathology

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

bioRxiv · Jul 24, 2020Cancer Biology