J. van Rheenen

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

The paper tracks cell proliferation in mouse intestinal organoids and shows symmetric proliferative behavior between sister cells minimizes fluctuations.

This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.

This study shows RASSF1C promotes amoeboid invasion, cancer stemness, and invasive extracellular vesicles through SRC/Rho axis activation in breast cancer.

This study shows that GFAP splice variants differentially regulate glioma cell migration and invasion, with GFAP{delta} depletion causing random migration and GFAP depletion enabling directional persistence.

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

The paper shows cancer cells in organoids eliminate wild-type cells through apoptosis and JNK signaling, promoting their own growth by forcing cell death and fate change in competing cells.

The paper introduces a photoswitchable tag technology to isolate and analyze live cells from specific regions in complex tissues, enabling spatially defined single-cell RNA sequencing.

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

The paper develops a stochastic competition model for stem cell niche access and validates it across multiple tissue datasets.

This study uses CRISPR to generate CRC organoids with different RAS pathway mutations, revealing distinct drug responses and growth patterns.