T. Xu

Crosslinking of Lipid Nanoparticles Enhances the Delivery Efficiency and Efficacy of mRNA Vaccines

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

An arms race between 5'ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

The paper examines the evolutionary arms race between 5'ppp-RNA virus and the MDA5 receptor in RIG-I-lost teleost fish, showing how MDA5 compensates for RIG-I loss and how the virus counteracts this through m6A methylation.

Nuclease-Resistant L-DNA Tension Probes Enable Long-TermForce Mapping of Single Cells and Cell Consortia

This paper introduces L-DNA tension probes that resist nuclease degradation, enabling long-term force mapping of single cells and migrating cell populations.

Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging

This study develops an automatic method to segment cerebral arteries and superior sagittal sinus from fMRI data, showing high reproducibility across age groups.

Synchronous assembly of peptide anisosome

This study reports the formation of symmetrical core-shell biomolecular condensates through programmed tetra-peptide libraries and identifies tryptophan's role in structuring these condensates.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Abscisic acid and GIGANTEA signalling converge to regulate the recruitment of CONSTANS to the FT promoter and activate floral transition

This study shows that ABA and GI signaling regulate CO recruitment to the FT promoter, enhancing FT transcription and influencing flowering time under drought conditions.

The main duct of von Ebner's glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections

Xylem perforation plate phenotypes affect water use and drought adaptation in maize (Zea mays L.)

This study shows that xylem perforation plate variation in maize affects water transport and drought adaptation through pleiotropic effects on root traits.

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

VRN2-PRC2 facilitates light-triggered repression of PIF signalling to coordinate growth in Arabidopsis

This paper shows VRN2-PRC2 represses PIF signaling in Arabidopsis under light to coordinate growth by setting a repressed chromatin state at PIF-regulated genes.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Rapid High-Throughput Isolation and purification of Chicken Myoblasts Based on Deterministic Lateral Displacement Microfluidic Chips

This study develops a microfluidic platform for isolating chicken myoblasts using deterministic lateral displacement, achieving 80% recovery and 99% purity.

Enhanced microbiota profiling in patients with quiescent Crohn's disease through comparison with paired healthy first-degree relatives using fecal metagenomics and metabolomics

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

Arterial mechanics, extracellular matrix, and smooth muscle differentiation in carotid arteries deficient for Rac1

This study investigates whether Rac1 deletion affects SMC proliferation by altering arterial stiffness or differentiation, finding no significant changes in ECM composition, stiffness, or SMC markers.

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging

The paper introduces a multimodal imaging platform to measure multiple cerebral hemodynamic parameters with high spatiotemporal resolution and applies it to study brain responses to hypercapnia.

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

This study identifies Akkermansia muciniphila as a key strain in fecal microbiota transplantation that alleviates gut barrier injury by modulating the Wnt/β-catenin signaling pathway in an ETEC infection model.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

High-Resolution Characterization of Human Brain Cortex with High-Fidelity Spatial Transcriptomic Slides (HiFi-Slides)

The paper introduces HiFi-Slides, a high-resolution spatial transcriptomic technique for analyzing tissue cell gradients, gene expression, and cell proximity.

Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules

This paper develops OGTACs, bifunctional small molecules that enable protein-specific O-GlcNAcylation in cells, with applications for studying and targeting this modification in disease.

Comparison between Canine and Porcine Models of Chronic Deep Venous Thrombosis

This study induces chronic deep venous thrombosis in canine and porcine models and compares their suitability for translational therapeutic research.

MiR-302-Induced anti-aging neural stem cells enhance cognitive function and extend lifespan

This study reprograms human fibroblasts into anti-aging neural stem cells using miR-302a, which enhance cognitive function and extend lifespan in mice with Alzheimer's.

Phytochrome higher order mutants reveal a complex set of light responses in the moss Physcomitrium patens

The paper investigates the light response mechanisms in mosses by analyzing phytochrome mutants, finding distinct roles for different phytochrome clades in sensing red and far-red light.

Microbiome features differentiating unsupervised-stratification based clusters of patients with abnormal glycometabolism

This paper identifies microbiome features distinguishing three patient clusters with abnormal glycometabolism, stratified using unsupervised clustering of clinical parameters.

Self-regulation of PIN1-driven auxin transport by cell surface-based auxin signaling in Arabidopsis

The paper identifies a cell surface-triggered auxin signaling mechanism that regulates PIN1-mediated auxin efflux and developmental patterning in Arabidopsis.

ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism

The paper identifies a mechanism where auxin signaling via ABP1-TMK1 receptor module stabilizes PIN2 to reinforce asymmetric auxin flow for root gravitropism.

ABLs and TMKs are co-receptors for extracellular auxin

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.