FcRn, but not FcgRs, drives maternal-fetal transplacental transport of human IgGantibodies
S. Borghi, S. Bournazos, N. Thulin, C. Li, A. Gajewski, R. Sherwood, S. Zhang, E. Harris, P. Jagannathan, L.-X. Wang, J. V. Ravetch, T. T. Wang
This study shows that FcRn, not FcγRs, is responsible for maternal-fetal transport of IgG antibodies, suggesting FcRn engineering could improve antibody transfer to the fetus.
bioRxiv · Mar 22, 2020Immunology