E. Harris

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

This study identifies GP38 as a viral toxin causing vascular leak and shows that specific GP38-targeting antibodies block this effect in vitro and in vivo.

A numbers game: Mosquito-based arbovirus surveillance in two distinct geographic regions of Latin America

This study conducts mosquito-based arbovirus surveillance in Nicaragua and Ecuador, detecting DENV in mosquito pools during the rainy season with varying infection rates between regions.

The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection

This study shows DENV NS1 activates inflammasomes in macrophages, leading to IL-1β release without pyroptosis, and that this pathway is protective against DENV infection.

Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells

This study identifies molecular determinants of flavivirus NS1 that confer tissue-specific endothelial dysfunction and vascular leak, highlighting the role of the wing domain and a three-residue motif.

Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

The paper analyzes genomic and phenotypic data from Zika virus lineages to assess fitness differences during the 2015-2016 epidemic, finding moderate fitness changes but no significant virulence or transmission enhancement.

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

This study shows SARS-CoV-2 Spike protein causes barrier dysfunction and vascular leak through integrins and TGF-β signaling, independent of viral replication and ACE2.

Transcriptomic Analysis of the Innate Immune Response to in vitro Transfection of Plasmid DNA

This study uses mRNA-sequencing to analyze how innate immune responses affect transfection efficiency in four cell types during plasmid DNA transfection.

An intranasal ASO therapeutic targeting SARS-CoV-2

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins

This study identifies NS1-dengue virus protein's interaction with human HDL as a mechanism to trigger pro-inflammatory signals during infection.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis.

This study shows that interferon receptor-deficient mice develop eschars and lethal disease upon Rickettsia parkeri infection, mimicking human rickettsiosis, and identifies vaccine candidates.

FcRn, but not FcgRs, drives maternal-fetal transplacental transport of human IgGantibodies

This study shows that FcRn, not FcγRs, is responsible for maternal-fetal transport of IgG antibodies, suggesting FcRn engineering could improve antibody transfer to the fetus.

Matrix Stiffness Regulates Liver Sinusoidal Endothelial Cell Function Mimicking Responses in Fatty Liver Disease

This study shows that increased matrix stiffness in fibrotic environments alters LSEC function, leading to capillarization and loss of endocytic ability, contributing to liver fibrosis progression.

T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species.

This study shows that T cell responses to flavivirus vaccines are specific and have limited cross-reactivity with other flavivirus species.

HLA upregulation during dengue virus infection suppresses the natural killer cell response

This study shows that HLA class I upregulation during dengue virus infection suppresses natural killer cell activity, potentially contributing to disease progression.

Peptide Arrays of Three Collections of Human Sera from Patients Infected with Mosquito-Borne Viruses

The paper uses peptide arrays and bioinformatics to analyze sera from patients infected with mosquito-borne viruses, aiming to improve serodiagnostics and epitope mapping.

A chromatogram-simplified Streptomyces albus host for heterologous production of natural products

This study creates a simplified Streptomyces albus host that can express foreign biosynthetic gene clusters to produce natural products.

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigens

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.

Early transcriptional responses after dengue vaccination mirror the response to natural infection and predict neutralizing antibody titers