T. T. Wang

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Spike Protein-independent Attenuation of SARS-CoV-2 Omicron Variant in Laboratory Mice

This study shows that the Omicron variant of SARS-CoV-2 causes milder disease and lower viral load in mice, likely due to mutations outside the spike protein that block post-entry processes.

Identification of Salivary Gland Escape Barriers to Western Equine Encephalitis Virus in the Natural Vector, Culex tarsalis

The paper identifies a salivary gland escape barrier in Culex tarsalis mosquitoes infected with Western equine encephalitis virus, showing that mosquito-derived strains transmit more efficiently than human-derived strains.

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen

This paper develops a stable cell clone system harboring self-replicating SARS-CoV-2 RNAs for drug screening, identifying three novel antiviral compounds.

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

FcRn, but not FcgRs, drives maternal-fetal transplacental transport of human IgGantibodies

This study shows that FcRn, not FcγRs, is responsible for maternal-fetal transport of IgG antibodies, suggesting FcRn engineering could improve antibody transfer to the fetus.

Afucosylated maternal anti-dengue IgGs are a biomarker for susceptibility to dengue disease in their infants

The paper identifies afucosylation of maternal anti-dengue IgGs as a biomarker for infant susceptibility to symptomatic dengue infections and explains its mechanism involving Fc{gamma}RIIIa-mediated enhancement of viral replication.