A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancer
P. Lo Riso, C. E. Villa, G. Gasparoni, R. Luongo, A. Manfredi, A. Vingiani, A. Jungmann, A. Garbi, M. Lupia, P. Laise, V. Das, G. Pruneri, G. Viale, N. Colombo, U. Cavallaro, , G. Testa
This study identifies DNA methylation differences between fimbrial and ovarian surface epithelia to create an epigenetic tracer that stratifies high grade serous ovarian cancer into clinically distinct subtypes with prognostic significance.
bioRxiv · Nov 30, 2018Cancer Biology