PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance
P. Parashara, B. Medina-Pritchard, M. A. Abad, P. Sotelo-Parrilla, R. Thamkachy, D. Grundei, J. Zou, V. Das, Z. Yan, D. A. Kelly, T. McHugh, J. Rappsilber, A. A. Jeyaprakash
The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.
bioRxiv · Feb 23, 2024Cell Biology