Author

P. Laise

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Califano· 3 shared K. P. Olive· 2 shared L. Tomassoni· 2 shared M. J. Alvarez· 2 shared W. Wong· 2 shared A. Andren· 1 shared A. C. Iuga· 1 shared A. Curiel Garcia· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

A. Califano

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

bioRxiv · Mar 19, 2023 · PreprintCancer Biology

Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection

P. Laise, M. L. Stanifer, G. Bosker, X. Sun, S. Triana, P. Doldan, F. La Manna, M. De Menna, R. B. Realubit, S. Pampou, C. Karan, T. Alexandrov, M. Kruithof-de Julio, A. Califano, S. Boulant, M. J. Alvarez

This study identifies host cell master regulators affected by SARS-CoV-2 and develops a method to find drugs that reverse their inactivation without harming beneficial immune responses.

bioRxiv · Jul 3, 2021Microbiology

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

P. Laise, M. Turunen, A. Curiel Garcia, L. Tomassoni, C. Maurer, E. Elyada, B. Schmierer, J. Worley, J. Kesner, X. Tan, E. Calvo Fernandez, K. Wong, U. Wasko, S. Tagore, A. L. E. Wang, , A. Califano

The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancer

P. Lo Riso, C. E. Villa, G. Gasparoni, R. Luongo, A. Manfredi, A. Vingiani, A. Jungmann, A. Garbi, M. Lupia, P. Laise, V. Das, G. Pruneri, G. Viale, N. Colombo, U. Cavallaro, , G. Testa

This study identifies DNA methylation differences between fimbrial and ovarian surface epithelia to create an epigenetic tracer that stratifies high grade serous ovarian cancer into clinically distinct subtypes with prognostic significance.

bioRxiv · Nov 30, 2018Cancer Biology