The IgH Eμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
O. Martin, M. Thomas, M. Marquet, A. Garot, M. Brousse, S. Bender, C. Carrion, J. E. Choi, B. Vuong, P. Gearhart, R. Maul, S. Le Noir, E. Pinaud
The paper shows that IgH Eμ-MAR regions limit error-prone repair to the variable region of Ig genes by promoting UNG-dependent repair, affecting somatic hypermutation patterns.
bioRxiv · Aug 15, 2022 · PreprintImmunology