Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a confirmatory cellular model
G. M. Pais, J. Liu, S. N. Avedissian, T. Xanthos, A. Chalkias, E. d'Aloja, E. Locci, A. Gilchrist, W. C. Prozialeck, N. Rhodes, T. P. Lodise, J. C. Fitzgerald, K. Downes, A. Zuppa, M. H. Scheetz
This study evaluates kidney injury from vancomycin and piperacillin-tazobactam in rats and cells, finding no increased toxicity from the combination compared to vancomycin alone.
Journal of Antimicrobial Chemotherapy · Feb 3, 2020Peer-reviewedPharmacology & Toxicology