M. H. Scheetz

Iohexol-measured glomerular filtration rate and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model

This study compares kidney function and injury biomarkers in rats treated with vancomycin, piperacillin-tazobactam, or both, finding no additive nephrotoxicity with the combination.

Impact of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a translational rat model

This study examines the effects of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a rat model, finding that higher doses correlate with greater kidney injury.

Hippocampal Concentrations Drive Seizures in a Rat Model for Cefepime-induced Neurotoxicity

This study identifies hippocampal cefepime concentrations as a threshold for neurotoxicity in rats, linking plasma exposure to seizure onset.

Glomerular function and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model.

This study compares glomerular function and urinary biomarkers in rats treated with vancomycin alone versus vancomycin plus piperacillin-tazobactam, finding no worsening of kidney function with the combination.

Urinary Metabolomics from a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury

This study uses urinary metabolomics in a rat model to show that taurine levels increase on day 1 of polymyxin B treatment and correlate with kidney injury markers.

Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships

The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.

The Pharmacodynamic-Toxicodynamic Relationship of AUC and CMAX in Vancomycin Induced Kidney Injury in an Animal Model

This study investigates the pharmacodynamic-toxicodynamic relationship of vancomycin-induced kidney injury in rats, finding that peak concentrations and fewer daily doses correlate with increased kidney injury.

Use of Therapeutic Drug Monitoring to Characterize Cefepime-Induced Neurotoxicity

This study evaluates cefepime-induced neurotoxicity by analyzing trough concentrations, clinical factors, and EEG findings in hospitalized patients.

Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a confirmatory cellular model

This study evaluates kidney injury from vancomycin and piperacillin-tazobactam in rats and cells, finding no increased toxicity from the combination compared to vancomycin alone.

Evaluation of Dose Fractionated Polymyxin B on Acute Kidney Injury: A Translational In Vivo Model

This study evaluates the effect of fractionated polymyxin B dosing on acute kidney injury in rats, finding that thrice-daily dosing caused the most kidney damage.