The novel Rab5 effector FERRY links early endosomes with the translation machinery
J. S. Schuhmacher, S. tom Dieck, S. Christoforidis, C. Landerer, J. Davila Gallesio, L. Hersemann, S. Seifert, R. Schaefer, A. Giner, A. Toth-Petroczy, Y. Kalaidzidis, K. E. Bohnsack, M. T. Bohnsack, E. M. Schuman, M. Zerial
This study identifies FERRY as a Rab5 effector that localizes mRNAs and ribosomes to early endosomes, impacting mRNA distribution and causing brain damage when disrupted.
bioRxiv · Jun 20, 2021 · PreprintCell Biology