PD-L1 - PD-1 interactions limit effector Treg cell populations at homeostasis and during infection
J. A. Perry, J. T. Clark, J. Gullicksrud, J. DeLong, L. Shallberg, B. Douglas, A. P. Hart, C. Konradt, J. Park, A. Glatman Zaretsky, R. de Waal Malefyt, D. A. Christian, A. H. Sharpe, C. A. Hunter
This study shows that PD-L1-PD-1 interactions regulate Treg cell populations at homeostasis and during infection, limiting their numbers to enhance pathogen-specific CD4+ T cell responses.
bioRxiv · Dec 9, 2020 · PreprintImmunology