C. A. Hunter

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-gamma on parasite restriction

This study uses single-cell RNA sequencing to analyze how intestinal epithelial cells respond to Cryptosporidium infection and IFN-gamma, showing delayed parasite reduction with cytokine treatment.

Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4+ T cell mediated resistance to Cryptosporidium

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.

Dendritic cell-mediated responses to secreted Cryptosporidium effectors are required for parasite-specific CD8+ T cell responses

The paper shows that dendritic cells are essential for CD8+ T cell responses to Cryptosporidium effectors, which are secreted by the parasite.

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus

This study develops an mRNA vaccine against clade 2.3.4.4b H5 avian influenza virus and shows it is immunogenic and protective in mice and ferrets.

PD-1 and CTLA-4 exert additive control of effector regulatory T cells

This study shows that PD-1 and CTLA-4 pathways additively regulate effector Treg cells by modulating their suppressive function and proliferation.

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis

This paper investigates how secondary TCR engagement affects CD8+ T cell heterogeneity during acute and chronic toxoplasmosis, showing its role in effector responses but limited impact on memory populations.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

A positive feedback loop controls Toxoplasma chronic differentiation

The paper identifies a positive feedback loop between BFD1 and BFD2 that drives Toxoplasma gondii chronic differentiation.

A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

This paper identifies a type III interferon response to Cryptosporidium requiring TLR3-dependent recognition, which protects against infection in mice.

Red Blood Cells Function as DNA Sensors

The paper shows red blood cells detect and bind DNA, triggering immune responses during infections.

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

The paper shows IL-33 enhances ILC-mediated resistance to Toxoplasma gondii by promoting IFN-γ production and reducing parasite replication.

PD-L1 - PD-1 interactions limit effector Treg cell populations at homeostasis and during infection

This study shows that PD-L1-PD-1 interactions regulate Treg cell populations at homeostasis and during infection, limiting their numbers to enhance pathogen-specific CD4+ T cell responses.

cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

This study shows that cDC1 in the omentum support T cell expansion and survival during Toxoplasma gondii infection, not T cell priming.

BATF3-dependent induction of IL-27 by B cells bridges the innate and adaptive stages of the antibody response

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

ThX - A next-generation probe for the early detection of amyloid aggregates

This paper introduces ThX, a new fluorescent probe for detecting amyloid aggregates, showing improved brightness and binding affinity over ThT.