Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
D. Y.-w. Lin, L. E. Kueffer, P. Juneja, T. E. Wales, J. R. Engen, A. H. Andreotti
This study presents the first structural analysis of full-length BTK, revealing conformational heterogeneity in the PHTH-PRR region and providing insights into BTK activation mechanisms.
bioRxiv · Jun 2, 2023Biophysics