Cell BiologybioRxiv
Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity
F. M. Omar, Y. Ichimura, S. Kageyama…·M. Komatsu
This study investigates how ALS/FTD-related p62 mutations affect liquid droplet properties, finding that some mutants show reduced Nrf2 activation and delayed turnover, while all exhibit slower inner fluidity.
DOI 10.1016/j.jbc.2021.101405