Author

A. Hernandez-Lain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

A. Perez-Nunez· 4 shared B. Herranz· 3 shared B. Segura-Collar· 3 shared J. M. Sepulveda-Sanchez· 3 shared P. Sanchez-Gomez· 3 shared R. Gargini· 3 shared D. Garcia-Perez· 2 shared Y. Ruano· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

A. Perez-Nunez

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4 papers

Recent·Most cited

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

L. Zhu, N. Yebra, D. Retana, L. Miarka, E. Hernandez-Encinas, C. Blanco-Aparicio, S. Martinez, R. Soffietti, L. Bertero, P. Cassoni, T. Weiss, J. Munoz, J. M. Sepulveda, A. Perez-Nunez, A. Hernandez-Lain, , M. Valiente

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

bioRxiv · Oct 16, 2020 · PreprintCancer Biology

The genetic status of IDH1/2 and EGFR dictates the vascular landscape and the progression of gliomas

B. Segura-Collar, M. Garranzo-Asensio, B. Herranz, E. Hernandez-SanMiguel, B. S. Casas, A. Matheu, A. Perez-Nunez, J. M. Sepulveda-Sanchez, A. Hernandez-Lain, V. Palma, R. Gargini, P. Sanchez-Gomez

This study investigates how IDH1/2 and EGFR genetic mutations influence vascular characteristics and progression in gliomas, identifying distinct vascular phenotypes and therapeutic vulnerabilities.

bioRxiv · Sep 21, 2020 · PreprintCancer Biology

Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature.

P. Sanchez-Gomez, J. M. Sepulveda-Sanchez, T. Cejalvo, A. Hernandez-Lain, R. Gargini, B. Segura-Collar, P. Mata-Martinez, B. Herranz, D. Cantero, Y. Ruano, D. Garcia-Perez, A. Perez-Nunez, A. Ramos, M. C. Martin-Soberon

The paper profiles immune cells in gliomas, identifying two immune profiles in IDH1/2 wild-type tumors and linking immune content to vascular alterations and Tau expression.

bioRxiv · Jul 17, 2020Cancer Biology

IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation

R. Gargini, B. Segura-Collar, V. Garcia-Escudero, A. Romero-Bravo, B. Herranz, F. J. Nunez, D. Garcia-Perez, A. Ayuso-Sacido, J. Seoane, J. M. Sepulveda-Sanchez, A. Hernandez-Lain, M. G. Castro, R. Garcia-Escudero, J. Avila, P. Sanchez-Gomez, , A. Perez-Nunez

This study identifies the IDH-Tau-EGFR triad as a key factor in defining the neovascular landscape of diffuse gliomas by regulating mesenchymal differentiation and vascular microenvironment.

bioRxiv · Oct 3, 2019Cancer Biology