J. Munoz

This study uses single-cell RNA sequencing to analyze a Caco-2/HT29 co-culture model, identifying cell types and assessing its similarity to human intestinal epithelium, finding it lacks some transporters and immune markers.

The paper tests if urbanization disrupts latitudinal gradients in seed predation across 14,000 km of latitude, finding that gradients persist despite habitat modification.

This paper identifies an allosteric switch between c-Src's activation loop and a c-terminal phospho-motif that regulates auto-phosphorylation, enzyme specificity, and non-catalytic function.

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

This study shows mast cells inhibit melanoma metastasis by reducing HMGA1 secretion, with HMGA1 expression linked to poorer survival in human melanoma.

The paper determines the structure of the RAF1-HSP90-CDC37 complex using cryo-EM, revealing how CDC37 regulates RAF1 and potential therapeutic targets.

The paper identifies CRF66_BF, a new HIV-1 circulating recombinant form of South American origin, distinct from CRF12_BF and prevalent in Paraguay.

This study identifies NFIC as a regulator of acinar cell differentiation and ER stress, showing its role in suppressing pancreatic ductal adenocarcinoma initiation.

The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.

This study examines how co-infections with Plasmodium falciparum and helminths affect antibody responses in Mozambican individuals, finding increased IgE and IgG levels in co-infected individuals.

The paper assesses microbial diversity and metabolome profiles in a hypersaline microbial mat across a small transect, revealing low taxonomic diversity and distinct metabolomic signatures.

This paper presents a mobile microscopy and telemedicine platform with deep learning for automated quantification of Trichuris trichiura infection, achieving high precision and recall in stool sample analysis.

This study shows that oncogenic RAS causes morphological changes in human epithelial tissues through differential mechanics, leading to three-dimensional structures similar to cancer behaviors.

This study identifies a cell cycle kinase-phosphatase module that restrains PI3K-Akt activity through mTORC1-dependent phosphorylation of IRS1 and GRB10.

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

The paper identifies a macrophage-tumor-initiating cell niche regulated by Wnt signaling that drives skin tumor formation and maintenance.

The paper identifies dsRNA mimics as inhibitors of lymphangiogenesis and metastasis using live imaging models of melanoma.

This study reports a 9.04% seroprevalence of Strongyloides stercoralis in migrant populations in Spain, with higher rates in Africa and Latin America and lower rates in Asian and East European populations.

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

The paper assesses the prevalence of T. cruzi, S. stercoralis, HIV, and viral hepatitis in Bolivian migrants in Spain, finding high rates of T. cruzi and S. stercoralis but low rates of HBV, questioning systematic HBV screening in this group.

This study identifies exosomes as key mediators of non-cell autonomous senescence by transmitting the senescent phenotype through a non-canonical interferon pathway.

The paper finds that post-dispersal seed predation increases from the Arctic to the Equator and from high to low elevations, driven by climate seasonality rather than productivity or biodiversity.