Chemical genomic guided engineering of gamma-valerolactone tolerant yeast
S. Bottoms, Q. Dickinson, M. McGee, L. Hinchman, A. Higbee, A. Hebert, J. Serate, D. Xie, Y. Zhang, J. J. Coon, C. L. Myers, R. Landick, J. S. Piotrowski
The paper engineers a GVL-tolerant yeast strain by deleting PAD1 and FDC1, enhancing ergosterol content and improving fermentation in GVL-containing hydrolysates.
bioRxiv · Nov 4, 2017Bioengineering